• 
  Racing – Estudiantes LP

  14 December

• 
  Brugge – Arsenal

  10 December

• 
  Real Madrid RM – Manchester

  10 December

• 
  Leverkusen – Newcastle

  10 December

• 
  Athletic Bilbao – PSG

  10 December

• 
  Benfica – Napoli

  10 December

• 
  Dortmund – Bodoe/Glimt

  10 December

• 
  Juventus – Pafos

  10 December

• 
  Villarreal – Copenhagen

  10 December

• 
  Qarabag – Ajax

  10 December

• 
  Atalanta – Chelsea

  9 December

• 
  AS Monaco – Galatasaray

  9 December

• 
  Inter – Liverpool

  9 December

• 
  Barcelona – Eintracht

  9 December

• 
  Union – Marseille

  9 December

• 
  Tottenham – Slavia

  9 December

• 
  PSV – Atletico Madrid

  9 December

• 
  Bayern Munich – Sporting

  9 December

• 
  Kairat – Olympiacos

  9 December

• 
  Atletico Junior – Deportes

  13 December

• 
  Santa Fe – Atl

  9 December

• 
  Libertad – LDU Quito

  14 December

• 
  Barcelona SC – Orense

  14 December

• 
  Delfin – Aucas

  13 December

• 
  Macara – CD Cuenca

  13 December

• 
  Independiente – LDU

  10 December

• 
  Emelec – Macara

  9 December

• 
  Manchester – Bournemouth

  15 December

• 
  Brentford – Leeds Utd

  14 December

• 
  Crystal Palace – Manchester

  14 December

• 
  West Ham United – Aston

  14 December

• 
  Sunderland – Newcastle

  14 December

• 
  Nottingham – Tottenham

  14 December

• 
  Arsenal – Wolverhampton

  13 December

• 
  Burnley – Fulham

  13 December

• 
  Chelsea – Everton

  13 December

• 
  Liverpool – Brighton

  13 December

• 
  Rapid Vienna – Omonia

  11 December

• 
  Aberdeen – Strasbourg

  11 December

• 
  Hamrun Spartans – Shakhtar

  11 December

• 
  Lech Poznan – Mainz 05

  11 December

• 
  Lincoln Red Imps – Sigma

  11 December

• 
  Shelbourne – Crystal

  11 December

• 
  KuPS – Lausanne

  11 December

• 
  Rakow – Zrinjski

  11 December

• 
  Rijeka – Celje

  11 December

• 
  Noah – Legia Warsaw

  11 December

• 
  Shkendija – Slovan

  11 December

• 
  Jagiellonia – Rayo

  11 December

• 
  Drita – AZ

  11 December